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Caffeine
Caffeine can generate weight loss due to being a stimulant. It is particularly effective when taken before a workout because it can increase the body’s endurance and ability to build muscle. More muscle means more calories burned, which in turn means a higher metabolism. It also helps in the breakdown of fat through the release of fatty acids, if taken before intense activity.

B-Phenylethylamine
This alkaloid is said to increase the metabolism because it theoretically stimulates certain brain chemicals. It is said to be a mood enhancer and to eradicate certain white fat cells - however, this remains highly speculative.

Synephrine or Bitter Orange
Synephrine is a substance that is derived from the citrus tree and is related to ephedrine (which is currently illegal). It is said to boost metabolism without the side-effects of elevated heart rate and blood pressure.